First off i realise that Morrowind is not a super stable game at all. When modded, it gets worse. However I'm having an issue where everytime i fasttravel or teleport in spurts, 2-3 times in a row, it crashes. I imagine it the memory leak issue. Is there a to purge memory? Either way, this is what i use

FPS Optimizer

Morrowind Enhanced

MWSE -.0.9.44? (i cant remember)

MGE XE (with the internal script extender one turned off , it used to cause crashing i think, but i havent tested it recently)

4 GB Patch

exe optimizer (pretty sure i did this)

INI files.. There are so many different tips for this, i dont know what i should set my ini like, i want to have the best looking experience but i want to be able to stop the crashing. I do have alot of mods, but it was pretty stable then i got to the point where i needed to fast travel alot more. Any advice? all the best

Always post your load order.

It could very well have to do with time, not the fast traveling itself (time passes quickly when you fast travel.)
Can you quickly reproduce the crash on a new game?

Morrowind Enhanced is well known to cause many crashes. Especially when used alongside as many mods as you seem to have. Knowing your load order would help.

What have you done to troubleshoot yet?
Start removing things (like MWE and MGE) and see what happens.