Well most of you know this is not been possible since Morrowind but I found a neat trick that does not require scripting/SKSE.

Add a perk to the player via a quest, then set weapon conditionals like getid weapID and BAM! You got a perk while you have that weapon equipped.

Need a spell you can do the same, set alias, set specific reference to player then drag and drop your spell to alias spells, have that spell with getid weapID or other conditionals. The down side is no info on the weapon of what it dose.

Can anyone think of any other way to give non armor/clothing a constant effect?