Now I've played this game a lot. More than 1500+ hours, if you count on both 360 and PC, but there are still somethings that I don't know occur in game or not:

• Does Ysolda ever buy the Bannered Mare?
• Does the Eldergleam ever blossom?
• Do the 'Dark Brotherhood Forever' quests ever end?
• Does the loot room in the Thieves' Guild ever get restocked?
• Does Nazeem ever understand that you HAVE been to the Cloud District?
• Can you ever find/help find Rune's family/past?
• Where/What is Wintersand Manor?

These are only a few, and I'm sure there are more, but I'm curious if any of these things referenced in dialog are actually possible in game/happen over time?

I don't think so.

Not sure

Probably not.

I don't know that one

Never. He will always ask.

Not sure.

And I believe it is a property near....I forgot where actually. But it is part of the Hearthfire dlc. Just google Skyrim Hearthfire and it should show up.

1) If Hulda is ever killed for whatever reason (vampire or dragon attack, psychotic player) then Ysolda will take over at the Bannered Mare.

2) You mean the tree in Whiterun? Talk to one of the priestesses, Danica something, she sometimes hangs around the tree. You can do a quest to restore it.

3) Yes, it's a never ending radiant quest for the Dark Brotherhood. At least without mods.

4) As far as I know it does.

5) No, not even his wife will miss him though, if something were to "happen" to him...

6) Nah, seems like Rune's story might have once been a quest that got abandoned somewhere in development.

7) Do you mean Windstad Manor? Is that one of the houses you can build with Hearthfire? I never got that DLC, so can't help with that one.

Oops, I meant 'Wintersand Manor'. You can get a key for it off of people in Whiterun, but there doesn't seem to be a house called that anywhere.