In the time of the Stormcloak Rebellion and the Dragon Crisis, the Thu'um was more or less a lost art, practiced only by the Greybeards and exceptions like Ulfric Stormcloak. However, Ulfric's use of the Thu'um in his duel with High King Torygg and the Dragonborn's wide us of the Thu'um to bring down Alduin and many other Dragons, could potentially cause a resurgence in the Thu'um popularity. This could mean that we could be seeing the Thu'um in some small ways in future games.
Tiber Septim founded the Imperial College of the Voice in Markarth Side, though no trace of the original College remains. Markarth and the Reach have and will seemingly continue to experience great change regarding the Reachmen, the Nords and Imperial authority in the region. As of the events of TES VI, we could be hearing rumors of a new College of the Voice in Markarth, where new warrior-Tongues are being trained in the Way of the Voice. Perhaps even a Tongue follower from there.