First of all, yes, I am aware of FISS. There are two problems with FISS though: Mods need to have support for it, and there are multiple reports of it not being thread-safe, meaning when multiple plugins try to use it, they step on each other and read the wrong XML file.
What I am looking for is a plugin that, upon creation of a new game, waits for every other plugin to load, and then when it does, starts changing the variables that these plugins use, like a batch script. Is there anything like that out there?