So, the first problem I met when trying to play the game was a instant blackscreen and crash when I start the game but I managed to get around this by removing the file GameIntro_V3_B.bk2 from the folder ...\Fallout 4\Data\Video. It's not a foolproof way to get the game to start as I have experienced the same crash even with this file removed but I can at least get to the main menu.

The problem I have now is that I crash when I select New Game. The screen goes black and I get the little green loading icon in the lower right corner and then after a while I crash to desktop. I've tried removing some of the other(both all at the same time and one by one) cinematics in the Video folder but it doesn't seem to work. I've also tried different settings (windowed/borderless, low-medium-high, different resolutions) and the result is the same. I also tested the beta patch you released and no change. I have the latest nvidia drivers (358.98 at the time of writing).

Inter Core i5 2.80 GHz

12 GB ram

NVIDIA Geforce GTX 660 2GB

Windows 7 64-bit