I read in an article that Bethesda plans on using the creation engine that Skyrim used.

http://www.vg247.com/2011/01/25/future-bethesda-titles-to-take-advantage-of-skyrim-engine-says-hines/

If there has ever been a point of criticism from my point of view it has been the awkward character animations in scripted events. Oblivion, Skyrim, Fallout 3 and Fallout NV have these scripted events play out like a bad high school musical. Actors walking awkwardly onto a stage to deliver a line with no real interaction with one another but staring in each others direction, accompanied by an occasional animation of crossing ones arms or pointing. Events taking place in these games would always disconnect me from an immersive experience.

I don't know if this is engine related, but in I felt this same vibe while watching the Fallout 4 trailer.

What do you guys think?

We simply don't know which engine Beth is using for FO4 yet. About animations the quality of them has almost nothing todo with the engine.