In the quest "end of the line" I can't enter the railroad code to get inside the room (the button won't press in). I can't progress any further in the main story unless I get inside and kill Desdemona.. And reloading the save does nothing. Please fix this!

I am also having this same exact issue. Please!!!!!!!

Did you guys open it earlier? I thought you had to go there at least once before in order to get this quest.

Yea I opened the door before. Still I'm stuck and this quest and can't "press" the button, I can spin the wheel... So frustrating to stumble across such a bug

Yep got this issue as well.