After watching the gameplay over and over a few times, I've come-up with a few points. These are not being sorted in positive or negative lists because, well, to each their own.
-I saw no reference or indicator to a degration or repair system for weapons or armor when the inventory system was shown
-The UI doesn't have the same style as the previous games and looks more simplified and...well...I'm going to be getting a UI mod ASAP
-I really hope power armor doesn't always bring with it that mech-mode thing.
-I'm interested how they plan on handling the skill/perk system
-The first BoS you see has torn-up armor. Either it recently got damaged (seems armor can break apart), or they aren't in the best of shape faction-wise
-The MASSIVE ship crashing to the earth has a BoS symbol hidden behind the flames beside (what I assume) is the ships name.
-Ability to build a community(s) is neat and I really just want to see more of it before I pass judgement.
-Custom weapons is fantastic, and it looks as though weapons have more stats to look at (range, rate of fire, accuracy, what looks like different damage types)
-Don't like animals spawning from underground. Seems like it would make it MUCH harder or Perma-death or more conservative players
Basically I like what I see, but really...we need more info. Hopefully in the coming weeks and months we learn enough to really see what's what. As of this moment, my only serious complaint is the UI. It looks kinda kidish, if that makes sense. Like they cleaned it up far too much. But that is a purely subjective opinion.