I cleared out University Point long before I ever received the quest Randolph Safehouse 1, that requires you to clear it out of Gen 1 Synths. When I went to the location, for the mission, it showed three active synths on the map, to be eliminated. After eliminating all synths marked, the mission did not update. It still continues to say Clear Hostiles at University Point. I have checked everything, Synths, creatures, eggs, etc. The map icon for University Park even states (Cleared) underneath the name.

I cannot progress forward with this mission or further missions from P.A.M.

I have the same problem, but it's told me to clear the boston mayoral shelter (which I cleared out a long time ago). the mission never even game me the mission marker once I picked up the thing from the drop zone, too. There were synths at the location, but once I killed them all, there was no mission update.

i guess it's wait until the patch time?