I'm having a weird glitch happen involving lighting and shadows. It creates a blocky edge around characters and different surfaces. It seems to only happen indoors as it happened in the house and now it's happening inside the vault. It didn't happen during the run to the vault. I have a picture, but I'm not sure how to share it. Thanks!

I'm getting the same issue too. Most of my settings are at low. Tried high settings and still get the blocky edges around characters.

AMD Phenom II X4 945
16GB DDR3
Radeon HD 5750 1GB
Windows 8.1 Pro 64bit

Whelp, I think it's definitely tied to shadow resolution, I've been tweaking it all day trying to get rid of shadows for objects and just leave the enviroment shadows on.
When I lowered below the low settings value of the shadows the white squares appear... Now, I'm speculating but the game has some LOD texture problems that cause low res textures to load... Maybe it's related and it affects shadow textures too?

Whatever the shadow problem is, there has to be a way to disable shadow rendering totally. You could do it with skyrim and FNV. So far, I haven't figured out how in the .ini files. The flickering of the shadows over the entire screen is just making me physically ill. May be taking my early Christmas present back for a refund.

Is it wrong for me to be happy that other people are having the same issue? Thanks for the replies hopefully this catches a spark.

I suspect the problem is from an incorrect error margin value for the depth of field shader pass (which probably is also tied into the Ambient Occlusion pass)
I was able to fix it myself and for several of my friends by editing these values in my Fallout4Prefs.ini and setting the INI file to read-only.

[Display]sAntiAliasing=TAAiShadowMapResolution=2048iVolumetricLightingQuality=2bVolumetricLightingEnable=1[Imagespace]bDoDepthOfField=1bScreenSpaceBokeh=1bMBEnable=0bLensFlare=1[LightingShader]bScreenSpaceSubsurfaceScattering=0bScreenSpaceReflections=1[BlurShaderHDR]bDoHighDynamicRange=0[BlurShader]bUseBlurShader=0

Tried it. Now my game crashes right as the actual game is loading up. It gets past the intro, gets to the main menu, I load my game, the loading screen comes up (and takes longer than usual) then I hear the sound of the game and it crashes.