This is probably my biggest complaint about fallout 4 from the trailer. It's been one of the main complaints I've seen in almost every single Bethseda game for years now, from Oblivion, Fallout 3, Skyrim, etc. I enjoy Bethseda games a lot (both TES/Fallout ) but the animation quality is just well it's subpar, especially compared to most modern AAA developed games from other studios like Ubisoft/EA, etc.
A few years back I remember Bethseda posting about acquiring a mocap studio, is it not being used for Fallout 4?
The animations come off looking robotic/stiff, rather then fluid and believable. Everything from the movement of characters to the facial animation so when they are talking, just looks a bit "off' and throws you into that uncanny valley feeling really quick because of the quality.
If I had one wish for the game, heck for any game Bethseda makes in the future it'd be for a completely revamped animation system that uses mocap and has fluid animations with the likes of games like Uncharted, AC, RDR, etc.