Ok this works for me with an underspec PC

Once the initial start screen load. Click options.

Then video.

Click on either a setting you wish to use, or reset. Click ok

Once youre back at the initial screen, click options AGAIN. This time remove the window format. Remove anialliasing if you wish etc. Click ok.

Now start the game.

This works for me with low graphic settings and with medium settings. However I do get the missing lockpick bug on medium settings.

If for any reason you exit the game or the game crashes, shut down the pc. DONT use restart or the problem continues. Shut down. Restart and try again.

Hope it helps. It does work for me.