After 5 hours of browsing various forums, and doing a whole bunch of debugging, I finally got Fallout 4 to launch without crashing, and in FULL SCREEN with full graphic settings!

First, my specs:

Windows 10 OS (64-bit)

Intel Core i7-4710HQ @ 2.50GHz (ThrottleStop @ 3.50GHz)

8GB DDR3 RAM

GeForce GTX 860m (Maxwell varient w/ 4GB GDDR5) (Stock, no DC/OC)

500GB Samsung 850 EVO SSD

Now for the exact steps I took.

First, I went to Documents -> My Games -> Fallout4 and deleted all the config files within this folder (I only had config files, if you've been able to play the game avoid deleting your saved game files).

Second, downgraded my NVIDIA driver to 355.82 (Clean Install using Display Driver Unistaller application to remove drive/registry keys while in Safe Mode, restarted my PC, and then downloaded the driver directly from NVIDIA site and installing it while in Safe Mode before restarting again).

Third, where I'm running Windows 10, I went to the game files and set both the fallout4.exe and fallout4launcher.exe files to launch as administrator and in windows 7 within the compatibility settings (right click the .exe, go to Properities -> Compatibility) (To get to game files, launch steam, click 'View" at the top left -> click 'Games List' in the drop down -> Right click on 'Fallout 4' within your list (be careful not to left click launch!)-> Click 'Properities' at the bottom -> Click 'Local Files' tab -> Then click 'Browse Local Files')

Fourth, disabled NVIDIA Streamer Service (Run -> MSCONFIG -> click on "services' tab -> sort by name -> uncheck box by "NVIDIA Streamer Service" -> click 'apply' -> click 'ok' -> exit)

Fifth, I launched GeForce Experience and made all graphic config settings changes through the optimization window (skipping this step will default Fallout 4 launching into a windowless mode at lowest graphic settings if launching in last step works).

Sixth, make sure Steam is launched and already running in the background.

Last, is to NOT launch the game through steam or desktop, but directly launching the game in the game files using Fallout4.exe (DO NOT CLICK Fallout4Launcher.exe which is what steam defaults to!). By launching directly through Fallout4.exe, the game will proceed to utilize the config files that were created through GeForce Experience and not Fallout4Launcher.exe which is reportedly bugged. Be sure to have Steam already running and then launch the game every time directly though Fallout4.exe or else the config files could potentionally get overwritten by Fallout4Launcher.exe and cause the game to crash on startup once again.

NOTES:

The first four steps may not be needed, as the fifth, sixth and last step could work alone for any NVIDIA setup where it bypasses the bugged Fallout4Launcher.exe. You can even just do the last two steps all together, but the game will defualt launch in a borderless windowed mode with low graphic settings by default, so either use GeForce Experience or another third party optimizer for those of you using AMD to allow the game to launch in full screen at your appropriate resolution and graphic settings.

I truly hopes this helps someone. Feel free to reply with your experience, or any modifications you may have done to get this guide to work for you and I will do my best to update this guide especially for AMD users.

EDIT1:

Added sixth step that involves having Steam running in the backgroung before launching Fallout4.exe thanks to CCNA's feedback:

Nice guide. I do want to add that you have to have Steam running to launch the game this way. If you don't, Steam will initialize then run the Launcher anyway.

Good to know! I had Steam running to begin with while going through this process so I never encountered this, but I will be sure to make note and also edit this in.

Thank you!

I think that geforce experience set your configuration files to run in bordless windowed mode, that's techincally not a full screen but a windowed mode(yes, you can play like that, it occupy the fullscreen, but it's different for many things).

Can you check your Fallout4Prefs.ini in MyGames/Fallout 4 and look for bFull Screen= (0 or 1?).

My computer:

Windows 8.1

Intel? core? i5-5200u CPU @ 2.20GHz

8 GB RAM, 64 bit

GPU Intel? HD Graphics 5500

My problem is when i turn on the game, the screen loads (turns black) for a few seconds then it turns off and im back on the desktop. i tried lowering the resolution, making the window small, updating through steam, i also tried updating the graphics card through the computer but it says it doesnt need it. i also tried updating the GPU through intel software, it didnt recognized my driver nor did it do an update. ive heard of people talking about down grading their GPU and i dont feel comfortable with that. I also set my settings for my graphics card really high with high battery consumption and backwards, nothing has worked. if i reinstall the game i can play till i get to the point where im on the elevator than it turns off and im back at the desktop. than i cant play again and im back to the loading screen thats black and cuts off. i was thinking that since the requirements for fallout 4 driver has to be AMD or NVIDIA but two of my friends who have intel hd graphics 4600 can run the game perfectly why cant i...

please someone help me, i payed 60 dollars for a game that doesnt work

promising solution but still did not work for me : /

bFull Screen = 1 and borderless = 1 when examining my .ini file. I made sure fullscreen was checked in GeForce experience, so that setting was carried over properly, along with various graphic settings as well.

Game has been perfectly stable for 12 hours worth of gameplay now with no crashing since I used the guide I posted in the OP.

Two problems with your PC specs, first your processor does not meet the minimum requirements. Secondly, you need a dedicated GPU. An integrated GPU, especially the one you have, just will not cut it. Also, your friends' Intel HD 4600 is actually higher performing than your Intel HD 5500. I have reason to believe your friends are lying to you if the game is playing perfectly with their setups, unless they forgot to tell you that they have dedicated GPUs (Nvidia/AMD), or by sheer luck they managed to get the game to run at min settings but I highly doubt their gameplay is smooth or running perfectly especially when they're near the bigger areas of the game.

That really svcks to hear. Hang in there, and don't lose hope.