One thing I hope they moderate a bit is the dismemberment factor. I mean, it's cool every now and again, but in Fallout-3 my sniper is ALWAYS taking people's heads off cleanly at the neck with headshots. Or the head explodes sometimes. And I have a very low luck, no Bloody Mess perk, no Finesse perk, no real critical boosts at all and it still happens nearly all the time.
I DO like the ability to cripple limbs or shoot weapons out of foes' hands. I was shooting outside VATs, once, and saw the foe's rifle PING away from his hands and then he turned tail and ran. Hilarious accidental stuff. There's a mod I have with a perk called Western Movie Hero which (allegedly) dramatically increases your chance to shoot a foe's weapon out of his hands in VATS. Haven't tried it, but it would be amusing, I think, to barge into a room with six foes and with a high enough AGI/PER just ping ping ping ping ping ping and then you're standing there with a smoking gun and six unarmed foes.