I've been searching the forums trying to find this glitch, but no-one seems to have had the same issues that I have.
When I attempt to pick a lock, if I encounter resistance when turning the screwdriver, the game repeatedly crashes within seconds of the pin rattling in the keyhole.
At the desktop, I get a double notification that the nVidia drivers have crashed and recovered.
The exact same type of crash (nVidia drivers crashing and recovering) takes place occasionally when fast traveling or loading a save (including from main menu).
I think this is an issue with physics object collision, but I have no way of confirming. Any community or Bethesda assistance would be greatly appreciated.