Find out what's happening, first of all. And the major population centres closest to Boston will be New York, Montreal and Quebec city. Whatever's standing, two out of those three will predominantly be a different language and culture and probably ally immediately, and the one that's not will probably be considerably more nuked.
So right off the bat, you better hope the French are friendly, let alone what's rumbling in the bronx.
Assuming they're not, you'd probably want to get as much territory and resources as you can. Maybe some of upstate New York, but New York city itself might be contesting that as well as Connecticut and Rhode island. The smart move would be to expand North and much as you can and get what's there.
Sorry... Playing out a weird sort of fallout rts in my head.... Maybe the basis of a new game, lol...