On many walls of the family's house, pre-war, there's picture frames. One was a beach, another was a pond with leaves or lilypads, but about 3 were of the same lighthouse. One in the hallway, one in the baby's room, one in the kitchen I believe.

Signs of DLC or possibly water travel? Maybe the Glowing Sea really is water and a dangerous path to traverse.

The LIghthouse is where you are transported either to Columbia or Rapture.

Another thread revealed the wife's name meant lighthouse, Nora is her name...I'd bet it has some significance

My guess is its just clutter to make it feel like the "Good Ole Nor East".

Some other things to expect are:

Bags of Humpty Dumpty potato chips.

Dunkin Donuts drive throughs.

Moxie.

Expensive heating oil prices for your settlements.

In game roads will look like actual New England roads.

Roof rakes as melee weapons.

Lobstah boats. Lobstah boats everywhere.

... unless you are a girl, and/or play female characters and change the name, the male spouse would then have to have a name that means lighthouse.

I disagree and think your reasoning is incorrect.

As to the significance of lighthouses, I really don't know.

Light houses do, in a way, resemble rockets, so, there could be some space travel metaphor going on, or, if you want to get all interpretive, there's the Freudian angle where every rocket, lighthouse, baseball bat, cigar, as well as every other phallic object is representative of something tied to sixuality, but, that's Freud.

There's certainly an actual lighthouse in the game. Perhaps the back-story extends to parents of the couple? You, regardless of whether you play as male or female could have parents that are lighthouse keepers, or you grew up in a lighthouse, or, your spouse has/had parents that were lighthouse keepers and grew up in a lighthouse. Pictures of lighthouses in the player character home would then make more sense, especially so where the lighthouse has an actual family history association.

If the devs have gone so far as to make the baby a composite of both make and female player character options, then, it's plausible that parents of the player character and their spouse, grandparents to the baby might also be included in some of the story, if only as a mention, and not ever really seen.

I have a painting of a lighthouse hanging on the wall in my house, but it's to remind my wife and I of the sea (none of that in Vermont!).

Lighthouse: a tower or other structure containing a beacon light to warn or guide ships at sea.

Nora: meaning Light.

I believe that if we choose to play as a male character, the red and white lighthouse, seen multiple times in the protagonist's home, will be where we finally meet our spouse during the main quest. This is where she will deliver a warning to the protagonist, a warning about Shaun. Note that the lighthouse is also a symbol of tragedy due to ships that do not make it and are lost at sea. For this reason, I believe that this location will also be our spouse's final one.

A quest to build the means to get to the lighthouse, whether via submarine or other.

It's more about the default names of the characters being a hint to the story.

Psssst Meet me here, I am the ugly kid in the corner drinking beer and watching the waves.

https://en.wikipedia.org/wiki/Boston_Light

I'll elaborAte I just think the light house will be significant ...because of default wife name...and because it's plastered everywhere in the house and concept art

So, Cobblestone?

I'd be down for that.