I was doing a quest that required me to kill two guys that were at the top of this bridge. When I got there, I started noticing for the first time ever, the game began to slow down. FPS began to drop dramatically, forcing me to restart the game, which would temporaly fix it but the more time I played, the slower it would get, forcing me to restart again until eventually upon restarting the game, it would crash.

Figuring this was probably due to a corrupt save, I reverted back to an older save only to see the same crash happen there too. I then reinstalled the game thinking maybe it was something in the main game files (and yes I also deleted the ini files in the save folder too) but upon starting the game again, the same crash happened.

Just a shame I put in over 4 days worth of work only to have this happen. BTW I did update the AMD graphics driver to the beta since I heard that would help with Windows 10 but it didn't help with this game though.

Shadow Distance set to 'console'(medium) will stop those fps drops. Hopefully a patch will be out soon, if not it is fixable by the modding community. I wouldn't hold your breath as the same thing happens in Skyrim @Hags End and the modding community said "bad light can't fix" and the issue persists to this day. I suspect same thing is the problem in FO4 but with way more occurances.

I actually set every thing to low but it didn't stop the crashes which started to happen afterwards.

I don't know about the crashing issue, but there are definitely areas in Fallout 4 that are FPS 'sinkholes'. I'm running a 980 ti with everything set to Ultra. I get 75+ FPS nearly everywhere (though I have locked my FPS to 60) - but a very few areas cause my FPS to drop to 40. A 35 FPS drop is INSANE.

One such area is the street intersection outside the entrance to Goodneighbor. Drops to 50 FPS, while other parts of the city, even from elevated vantage points, stay at 60 FPS or higher.

Bethesda definitely needs to optimize some areas. I'm kind of horrified what other users are experiencing in these areas if I am seeing a 50% framerate drop on one of the most powerful cards on the market.

Yeah it started happening in that area and some effected the rest of my saves. Outside of one game ruining bug from a quest that I figured out a work around to, the game was working just fine until that point. BTW my Video Card is an AMD Radeon R9 280 3GB

UPDATE: When that last update was annouced followed by people with the same problem as me with bad saves complaining about the source being the quick saves, I decided to update the program and delete all my quick saves. Apparently that did the trick.....for now but I got this feeling this is actuall a memory leak problem just like the last time with Fallout 3. If I am correct in another couple of days I'll find out if it is and we start this crash problem all over again.

Wish me luck