Soon after you are leaving the Vault you got shot in the head and you don't remember anything about your past anymore. But it isn't allowed to be called amnesia because amnesia is a cheap overused plot device.
At least it allows you to forget all that past crap and can make your own character.
Then you get some clues to get your revenge. You know revenge that absolutely not over used plot device. To help you out and so that newbs don't have troubles with the game a robot follows you arround and fights for you if you get in trouble, which isn't a carbon copy from a another game, absolutly not.
After you made your way through a linear path (that sure can be cheated because a invisible wall was forget to set) you reach the big city. Get your Fallout typical conversation with a big computer which isn't a big computer (except most of the time you talk to him) and get your revenge.
Then a ton of meaningless little bringin and go there and there quests happen. But hey they are a ton of quests which are clogging your pipboy and they are more then ever.
Then tells you the game developer that you are actually a greedy bastard which doesn't appreciate glorious game design who he think is hard. Learn about religion because you know these gamers have no idea about religion and its such a great game making concept. Get some very bad collegue humor jokes ...you know the [censored] ones... to end with nuking the whole thing again because actually the game developer doesn't know much todo with the Fallout universe anymore.
Not without adding a past to you again ... which surprise, surprise, ... you didn't know about and it was never intended to slap on the player (as promised a thousend times before release)... But you know the player doesn't know how to play and appreciate that glorious game so let the game devoloper great big NPC do it.
Ooops I think that was already done . (Btw. you can do that stuff with every game or artwork in existence, it's not my full opinion about NV only a demonstration of the method.)