OK - the Fallout 4 Mods topic does not cover this.
We know the Creation Kit will not be available this year, but that does not say we can not start getting ready.
Start with general questions:
1) What game engine will Fallout 4 use?
2) Is it script compatible with either Fallout NV or Skyrim?
3) Will there be any conversion tools available to help migrate from either Fallout NV or Skyrim?
4) Will our normal modding tools like Blender and 3DS Max work with the textures and meshes in Fallout 4?
5) Will Fallout NV Textures and Meshes be directly useable in Fallout 4? What will we have to change?
6) What is the best direction for user added animations in Fallout 4? Zaz or FNIS?
7) Are Scripts internalized, AKA Fallout NV, or externalized, AKA Skyrim. If the latter, we need a Save Game Cleaner.
Now specifics:
1) What will Mod Organizer need to start developing for Fallout 4?
2) What editor base do we use - TES5Edit or FNVEdit? And how soon can work start on it?
3) I think Wrye Flash / Bash has been supplanted by Mod Organizar. Anyone still see a need for it?
4) We definately will need a robust script extender. Based off Skyrim or Fallout NV?
5) Power Up tools for the Creation Kit (GECK, etc).
6) Any other tools we need to make successful mods?
7) General: Encourage Bethesda to release a robust Creation Kit. The ones for both Fallout NV and Skyrim are pretty fragile.
Note: This is not the topic for "What is the point in mods". Go post in Fallout 4 Mods.
Posting in this topic should mean you know what the point is.
If there is anything I can do to help in any of these areas, let me know. Being retired has it's advantages.
Lets hit the ground running on November 10!