Should we expect better than witcher 3 graphic quality with rocks, water, lighting etc or is the game more than likely to require several mods to get to that point
No idea what you're asking with that first bit.
I do expect it to be "better" graphics than Skyrim, since it isn't being developed for previous-gen consoles.
I don't expect it to look like Witcher 3 or Crysis.
We have no idea about HD texture packs released by Bethesda quite yet. The only thing thats certain is that PC users are going to be able to render it at whatever high resolutions their monitor can support. Bethesda hasnt really pushed the graphics of their worlds since the Morrowind and Oblivion days, but then I could fill a entire thread with speculation as to why that is. What you see in the pre-release footage is going to be close to what you get on consoles I guess. Pushing the resolution and 60 FPS is the only way you can improve on that on a beefy PC that I am sure some people have bought for Fallout 4.