Yes, I'm playing for hours and hours, which might not be healthy for the eyes. But I've been able to do so with other games without any problem.
I'm kind of obsessed with looting everything and making sure I don't miss something. I don't know if this is the reason why I'm getting eye strain, but it feels like it could be (one of) the reason(s). The continuous and repeating movement of the eyes when you look in the middle of the screen and then read the text that pops up to the right when you're about to loot something is eye straining in the long run.
I wish there were a way to move that text more to the middle, or even disable it. Or having it popping up when you're about to loot something you have a search tag for.