The issue with Fallout 4 crashing so often as Bethesda already knows is a RAM / VRAM related issue due to the game's lack of optimization. If you have a Graphics card that has VRam of 2gb or less you will CTD (Crash To Desktop). The higher your visual settings are the more often you'll CTD even despite having 30fps. If you're RAM can't handle all the cache that comes from the game it will cause Driver Failure. AMD has not made any updates on this nor has the latest Beta 1.2.33 patch helped at all. The only way to prevent the CTD from happening as much or constantly is to lower Visual Settings EVEN MORE than you already have (IE lower distance stuff, lower resolution). Even then the game will still CTD no matter what you do (5-45mins until CTD is what I get). People with higher end GPUs will not experience this problem as much or at all. But anyone with 2gb of VRam or less (or even 4gb or less) will still CTD randomly.

I'm on R7 200 series 2GB VRAM, 8GB Ram, i5 6600K Processor. My OS is windows 10 64bit and I play fallout at lowest settings for everything besides godflare and resolution. I still randomly CTD depending on what I'm doing 5-45 minutes at most. To be sure it's not just my low end specs I've done research on the RAM usage of everything and I shouldn't be having this problem (Unless of course the game isn't optimized correctly or has memory leaks)

(VRam 2gb + Ram 8gb) - (2gb OS + 3gb max fallout) = (50%) rather 30-70% of ram possibly used.?

I hope this clarifies the Fallout 4 CTD issue for anyone who's clicked every link on the first 10 pages of google looking for a solution. The latest Beta Update and the latest AMD Drivers have not yet fixed this problem for above Minimum Specs users. This game simply should not have been released so early with literal game breaking bugs such as this. I've been a huge ES fan for years and recently got into fallout4. Needless to say I'm extremely disappointed with the magnitude of this bug. As a Bethesda really devoted fan I obviously am used to semi game breaking bugs but this one is outragous and the degree of ignorance and problems revolving around it is a lot to take in. Hopefully as I type this the developers are fixing this issue.

Temp Solution: Set everything to as low as possible. (OFF, LOW, or MEDIUM) and turn Distance display down for Items, Actors, Objects and whatever else. (this can prevent/cause CTD)

Even if you make 30+fps in High/Medium settings, the CTD will still happen.

Thanks and goodbye.

I'm still not able to get past the main menu, but at least with this, I can get further into a loading screen before the driver stops responding than I could before. Usually. Has to be in 800x450 windowed mode as well, for it to have any effect for my comp. Still, I'm glad to have some progress, than be stuck where I've been for two weeks.

What OS, GPU, Driver Version, etc.. do you have?

I have a 2 gig GTX 750 and the game has not crashed yet. The other aspects of my system is just above minimum (A10-6700 APU) with 8 gigs ram. This game has been the most stable game from Bethesda which is surprising.

I have only played a few times on the pc at over 22 hours but two of those sessions were over 8 hours played straight.

I also play on the Xbox One.

Someone else said they had a R7 260x (mine is a 250) 2GB VRAM 8GB RAM and they were fine as well. However they were able to get 50fps on Ultra settings, so I assume their graphics card was just good enough or something. Also were you running an original Fallout 4 version? Did they do something to the game or has this problem persisted since launch? I've tried everything there is to fix the CTD issue but nothing has helped. And from what I gather from other people it seems to be the lower end GPUs that do this even though they meet minimum requirements and don't "lag" in game with lower settings.

I got the game on the PC on Friday the 13th.

I can play on Ultra but I play with Medium textures since I do not notice that much of a difference in quality at 1080p. I set the god rays to low (I do not care that much for that feature). I set the shadow distance to Medium since Shadow Distance is one of the biggest FPS drains especially in some sections of the game. I usually do not notice it that much and prefer to have the game to have a stable FPS. I play full screen.

Are you getting an error code?

Did you do a clean install of the videocard drivers?

Not like when an application normally crashes, just a message in a speech-bubble in the bottom-right corner stating that the display driver stopped responding and has recovered. It vanishes completely if I try to click on it, rather than give me more details about the event. And yeah, I've done clean installs, attempting multiple driver versions.

I'm actually glad to hear you're having this problem as well. I think for sure now bethesda is going to fix these issues pretty soon considering it's not just AMD R7 series drivers.

Whatever this problem is hopefully it gets addressed in the OFFICIAL update.

After seeing these forums and else where having all these people with the same exact problem I'm more than sure this is a problem that can be addressed and fixed.