TGM or toggle god mode gives you access to almost all of the crafting items except the stores. Which can make base defense easier if you don't like risking your life to protect your settlement.
That wasn't what was asked by the OP and it also gets into outright cheating, as it allows you to build anything with unlimited resources.
Sticking to what was actually asked:
OP: Yes, you can use TCL to help base building, and I've done it. I wanted to add lighted to the top of the tower in the movie theater complex and TCL enabled me to get up there (otherwise it's inaccessible). It doesn't break anything, but there's at least one quirk: you can't attach wires while in TCL mode. So you have to toggle it off, attach the wire, toggle TCL back on and fly up to where you want the wire, perch yourself somewhere, toggle TCL back off, and attach the wire at the other end, etc.
Yeah for one of my tall buildings I had to make scaffolding to make my house LOL