Drunk, as in

Alcohol: +1 STR, +1 CHR, -1 INT

? Absolutely

there were plenty mods that did this. the game brought all the resources (models etc) needed to do them too.

that's pretty unsatisfying for _all_ fallout drugs (and tes, speaking of it)

tried a couple drunk-mods (both fo and tes), but they all either had few noticable effects at all or desperately needed tuning ("totally stoned"-or-nothing fx) -

edit: admittedly though, a good drunk mod would be harder to do than any other drug, since it directly affects movement = controls, which are pretty hard to influence, while for pretty much anything else, you'd get away with some visual fx and tuning player stats

only drug related mod i really like is some "marijuana.esp", for it's fine tuned visual effects, degrading over time and different effects for every sort,

don't know the author though since it mysteriously disappeared from steam after just a short while, can't tell if the author took it off or it's been removed (might be because this was a skyrim mod and the games 16+, wouldn't be acceptable for fo or any other 18+ title though)

Mods are one thing, it would be great to have it as part of the game itself.

We you get knocked down in Fallout, Elder Scrolls, the camera pans out to third person. Imagine getting knocked off a cliff or something and barreling down the side of it in a first-person panic.