I personally found this interview rather intriguing, especially the organic nature of radiation and the weather system. - https://www.youtube.com/watch?v=DqQqeEgWb7Q

He also reveals that there will be an area where "the bomb dropped" that will be highly radioactive, maybe reminiscent of the Glow in Fallout 1(that's my conjecture)?

Yessss.. It's good stuff. Radiation storms sound freaky.

I like the fact that our companions can get knocked out or disabled during battles until we heal or fix them.

http://www.gamesas.com/topic/1521918-fallout4-interview-and-gameplay-videos-thread/ and http://www.gamesas.com/topic/1521898-new-todd-howard-interview/page-2 are already discussing it. I'm hoping this place is actually highly radioactive to the point that we can die instead of a slap on the wrist for not preparing and what not.

"When lightning goes off you get irradiated"

What?

The place is called the Glowing Sea, so I wonder if that will actually utilize the bay area or if it is just a big strip of land.

I believe it's the same area of land where the Deathclaw is shown in the trailer.