I had some weird behavior with a script that was actually being clobbered by a different script that had an endless looping problem as well. But I was able to pause the game (by going into the wait menu or pipboy for example). I would be curious if your tried this, and the game responded by opening the wait or pipboy menus, would your cursor come back?
Er... no, I mean, it was impossible to even start up the game in the first place. The opening credits couldn't be clicked through, because I didn't have a cursor, and even when I waited through them, no menu options would come up to let me do anything. I had to exit using Control-Alt-Delete.