The sole survivor will find his/her wife/husband has become horribly mutated like the master in FO1 and his son was killed by the mother/father for not wanting to assimilate with her/his army of highly intelligent centaurs. If the wedding ring is equipped while in conversation with her/him you will have a chance to talk her/him into self destruction as long as you have high enough charisma (90+) and luck (at least 5).

And the best part of the Junk Jet is that you can add an Electrification Module or Ignition Module. Just imagine firing flaming teddy bears of doom at your enemies.

Bethesda and especially Fallout is pretty known for its "easter eggs" and such. I wouldn't be surprised if there's any pop culture references to skyrim since its been their biggest project until now.

Whether its a guard referring to being an explorer once and getting shot in the knee lol

or some crazy guy yelling "FUS-Ro-DAH!"

or an entire town is out for blood after someone kills a chicken XD (i know its happened to ALL of you) which does not sound like a bad idea for a quest. Find the chicken killer before the town goes mad with rage lol.

This is speculation or fact? Because that would be really awesome!

That explains why I never used one in Fallout: New Vegas, lol. I though Rock-it Launcher was a pretty cool name actually. Last night I loaded up Fallout 3 and was going around killing things with it ~ killed a couple of deathclaws with coffee mugs. What a riot!

Please please no aliens. I don't mind a single goofy encounter or weird conspiracy theory, but I don't think they belong in the overarching plot.

It's a fact, you can see it during the weapon crafting segment of the E3 footage.

Ghouls racing boats on the Charles. And public hangings on the Commons.

If you shatter the glass bowl of the alien helmets, their heads will explode. https://www.youtube.com/watch?v=GSbigjiKLoU.

Another crazy preacher. We saw one in the church of atom in Fallout 3 and another in worshiping Talos in Skryim. We need another loud mouth to brighten our day.

And Boss battles, we saw the Deathclaw we have to fight at level two, I am hoping Bethesda put more things like this in game.

Don't forget the dude by Dupont Circle or maybe Georgetown who had a whole alley rigged with mini nukes. This is probably a certainty, and maybe even a small faction. I could see an anti-technology Luddite group gaining traction, kind of a foil to the Brotherhood of Steel.

As for boss battles - mirelurk queen is a confirmed enemy, and I recall a mention somewhere that Skyrim helped them refine large-scale enemies like dragons, so expect to see more of that.

Lee Eremy is confirmed as an NPC. His role is your old drill sergeant that has been ghoulified. He will get you back into fighting shape after the being in cryo or drive you to commit suicide.