Yeah I read that up now and even made a thread summarizing it all but it got deleted. This is why I did not like the ME Dragon Age system. There is too much room for misinterpretion. You get three keywords maximum, how is anyone going to make sense of that? You can not judge the complexity of an answer by three words. I am deeply appalled by the dialogue system.
He also said, that there was basically no quest yet that you could solve with talking only. That is a huge disappointment. There are perk and stat checks though, at least.
As for Karma there is nothing you can measure really, only a "X approves of that." And from Telltale Games we know how much that really has an impact on gameplay. None.
He did say that he made a choice with direct impact on gameplay, however nothing as large or meaningful as Megaton.
From what I see they dumbed down or cut game aspects like Karma and Dialogue and emphasized more on the weapon modification and building of settlements. Two features that I do not care about. Our spanish player says, while he likes that, he fears that they put so much work into these features, that Fallout 4 lost "weight" in other core aspects. Time will tell, but I am not really happy about what I read concerning these features.