The following video reminded me of Fallout, and what I thought could be an interesting expansion. Asking the question, "Whatever became of the people living in space?". After the Nuclear Annihilation, did they try to get back to Earth or to the Moon Colony? Or might they have just slept in suspended animation for some time. Only to wake up, to a space station falling apart around them & a wasteland of a planet down below.

"Von Braun Space Station 1956"
https://www.youtube.com/watch?v=5JJL8CUfF-o

Another premise I'd love to see. Would be a full game similar to Fallout Shelter, and maybe in-line with the above. The player is plugged into a Vault as a human computer. You're job is to manage the Vault via the machines & maybe by moving your consciousness into upgradable robots. The Dwellers being AI characters, may not always do as you wish, having personallities of the own. And with your limited abilites, you will have to guide them through all kinds of dangers. Be it expanding the vault into unknow caverns, moving your Dwellers to the surface & building a city, or simply fixing a leaky radioactive pipe... who knows?

Just an idea...