Ok, so I watched about 48m of the video and here is my honest feedback.
1) You should be using Twitch rather than YouTube for this kind of game. Having an audience to interact with would add more interest. Allowing your audience to interact with you in real-time and vice versa adds value and makes it more interesting. Watching an hour long YouTube video of 2 people I never see play thru the first part of the game Ive already played through is kinda boring.
2) Your videos should be shorter, 20-30m tops. If you utilize Twitch then your YouTube videos should just emphasize the highlights with voice over commentary. This gives you time to point out the important bits while providing feedback to new players and also gives you time to research if there are alternate routes to take while making decisions.
3) Kira needs to be more vocal if she is going to be 1/2 of the presentation. Most of her replies were 'Yup' 'Yeah' 'Yeep' etc..
4) When using terminals or accessing notes its important to read out loud what you are reading, I was 'watching' this while working so it was on another monitor I wasn't looking at all the time, hearing you comment on something you read without actually reading it aloud gave no context and left a lot of empty air which doesn't help to garner my attention.
5) You seem to be a die hard Fallout fan as you know the history of other vaults, characters, locations, etc. So try to incorporate that into the play time by providing context and background info on these items whenever they are relevant.
6) You're playing for an audience so you may need to adjust your play style to provide more entertainment, otherwise its just watching you play the game for the hell of it - which brings me back to point 1, you should be using Twitch. Look at Overboard Gaming, they are a 2 man team that stream daily and they make it work and are pretty entertaining guys.
Just my .02 cents
It wasn't terrible but it definitely needs some work if this is something you plan on continuing throughout the life cycle of the game.
6/10 - would probably watch again in the future