These are just ten things I hope they either fixed, did better, or added from the past games in no particular order:

1.Interesting Story
All of the past BGS games haven't really had a story I cared about. Maybe it's just the way the game works, but I hope they learn from what the audience did and didn't like from their past games.

2.Interesting Dialogue
So this one they'll definitely advertised with their "over 100,00 lines of dialogue", so it haves the potential to have interesting dialogue, even more so with a voiced protagonist. My hopes are just that they can follow through with it.

3.Good Perks
Again they'll advertised their new leveling system I just hope it's "feels" right. What I mean is for example in Skyrim where there were only a few perks that really felt like you were doing something different once you got the perk, like the archery perk where it would slow down time or the perk that you could draw your bow faster, stuff like that. I don't want all of the perks to just benefit the numbers of the game like like damage or damage resistance.

4.Rubber banding system done right
I hope this is done right. I can't say how much I hated how they did this in Skyrim. Instead of hard enemies and easy enemies almost all of the enemies just leveled with you. "You just turned level 50? well instead of getting revenge on all of those raiders, we're just going to make them the same level as you," the feeling of progression is necessary, but without a level cap the chances of this feeling successful is low.

5.Good Customization
Again, they showed enough of this that it seems perfect, I just hope it follows through

6.Easter Eggs
I know BGS ALWAYS puts easter eggs in their games, I just want them to keep it up, with both funny easter eggs and serious ones, like references to other games (specifically New Vegas).

7.Karma/reputation system
Still an interesting system but one of the biggest things that needed improvement in F3 and FNV. You know like more consequences for doing the wrong thing, not getting bad karma for pickpocketing a raider, etc. Especially doing what they did with the rep. system in NV, say what you want but I loved it and I hope they can implement it still and work on more.

8.Settlement building
Just like the customization that I mentioned, they'll shown it off and BGS is proud of it, I just hope it follows through and is as fun as they are making it seem.

9.Music
I can't tell you how much I loved the music in F3, it was fantastic, and with the songs they put alongside their trailers, I have high hopes that they're going to put just as good of a soundtrack into F4. On top of that, I hope they put some of the songs from F3 into F4 for nostalgia's sake (and save me the trouble of getting a mod to do it).

and last, but certainly not least......

10.Better AI
Ok, we all know the AI in past BGS games, were a little....... lets say "dumbed down" and I think we can all agree that the AI still needs a little work down, so this is hopes that they listened and put a little "mmph" into the AI.

So what do you want differently out of Fallout 4? Is there something you want them to take out that they've had in previous games? Post away!

If they took any inspiration from RAGE for the AI, even a little, it would go a long way for this game.

6: I think we will see Cheer's in Fallout 4, that would be a pretty big Easter Egg.

https://www.youtube.com/watch?v=iszxGLja2wg

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1) Stable FPS

2) No Stutter

3) Good first person shooter, handling, feedback, and smooth scrolling for aiming.

4) No need for massive amounts of numerous workaround hacks to correct these.

Although when playing Skyrim it would seem that for the most part those issues are not as naggingly obvious or much reduced. If the same holds true for Fallout 4 well it'll be a heck of a good game.

Hopefully the min and req specs are indicative of a very wide range of hardware that will function well with the game.

I am pretty dang easy to please.

I just want to able to waste as Much time enjoying this game, as I have all the other fallouts.

OP, I think you can narrow that all down to "I want an enjoyable game". As do we all. As do we all.

I've just realized that we've yet to see if the reputation system is in New Vegas... I'd wager that it's not.

So far, it looks great to me. Nothing I can hope for. Everything I want is already confirmed in the game.

If there are multiple factions that you can side with, I would think there would be some sort of system that manages what each group of people thinks about you.

If you recall the E3 Game play Coverage with the Ghouls in the supermarket, their animation look a lot like Rage.

Yep, I noticed that. I'm sure when iD wasn't working on DOOM they through their two-cents in with Bethesda. Might as well, Beth in my opinion has really brought them back into the spot light along with Arkane and... well pretty much whatever they touch might not be the best game, but is certainly quality. I am actually proud that they would cancel Prey 2 and put that MOBA game they were making on hold because they thought it didn't meet quality standards. We need more Bethesda, less EA (though honestly I love EA to, just not all their practices) Could you imagine Mass Effect and anything from DICE being produced by Bethesda?