Just today I experienced a very odd situation:

I played the game and changed during gameplay the main monitor (Windows -> Primary Monitor) in order to see the current time.

My primary monitor is 27", my secondary 19" (obviously different resolutions).

Everything ran fine until I tried to start the game the next day. Then it crashed every time after the Launcher.

This issue was resolved after changing back the screen to the old configuration.

Apparently the game does not like hardware resolutions of the primary monitor to change (which could happen if someone buys a new monitor).

Obviously this would be a issues which will only occur on PC platforms.