Unfortunately, for me, if there no quests theres nothing to work towards, i fear that finishing the main quests will make the game a bit stale like previous Elder Scrolls games. Whenever i play those these days i take the time to do the faction quests first before even going to Whiterun.
Ive already done all the side quests i could find including Yangtze. Ive found special items like the Mascot Head, X-01 armour, have full Heavy Combat armour and 2 Super Mutant looking arm pieces that call themselves Heavy Metal Armour, i still need to max out follower options but learning about Piper's bonus perk at this stage in the game is somewhat pointless. I'm sometimes eager to try and max out the game for as long as i can, i want to get more perks unlocked so i can experience more things without having to take precautions.
But if i progress with taking out the Institute or one of the other factions i will run out of tasks and have to make my own fun, which again would be fairly easy if i hadn't already found all settlements bar BunkerHill, and used up all my wood building defensive walls around them. the first instalment of DLC can't come soon enough for me but I'm sure ill be waiting a long time unless they go down the path taken by the Witcher 3 in where they trickle out missions every month or so for either free or a small fee like £/$1.99