Here's a list of weird bugs I've seen.

1) Instead of a settler from Sanctuary giving me a quest to kill some ghouls, it was a caravan guy at the settlement. So after completing the quest when I ported back to Sanctuary he wasn't there, he was trekking across the map......when I tried to port to his location on the map because of the time elapsed on fast travel he had moved on so I could never catch him using fast travel. I had to guess where he was going to be next, port ahead and run to him physically while checking my map repeatedly to see where he was moving. \

I did complete the quest when I reported in though.

2) I completed all the Cabot house missions for Jack Cabot. After a few days he tells me to go back to the asylum to get an item. I go there, he isn't there, he's somewhere else on the map and moving towards the asylum.........I get there and again like the caravan guy he's moving. Then he stops moving, the quest locator shows he's in the ground in the middle of nowhere, I can't find him or a dead body. I assume he was killed on the way. A NPC on a quest can be killed enroute?

3) On "a nuclear option" quest for the railroad fraction. I port in from the railroad to the institute and have to get to the relay room to kill everyone. Instead of being able to get up (I checked walk throughs on youtube) like I should be, the elevator isn't working and the entire institute is empty?

4) Just getting stuck between objects and walls......

I've had a couple where quest NPCs wouldn't talk to me, but it resolved after saving, exiting the game then restarting and loading the save.

I've been plagued by the missing limb bug and the quest in Vault 81 with the junkie and his sister; I completed it but when I told her to go to Sanctuary it still says "Talk to what's her face's name." Yeah, I can't remember her name.