Since finding the silver shroud costume I have decided that I am never taking it off - I just love the look of it so much I don't care if I get one shotted by a radroach that baby is staying on, and as in previous Fallout games I do not ever use stimpacks in the heat of battle and try not to pause the game to switch weapons etc during a battle. I also don't reload save points if I fail a speech check and I try not to fast travel anywhere - although I do allow a fast travel back home to dump crap and then back to wherever I was.
I just wondered what restrictions you place on yourself? Fallout is such a personal experience I am sure that you all have some great ways that you enjoy the game in your own unique way.