For me it's super mutants, if I'm going somewhere and I see sm's walking down the road, or an outpost. I'll pause, check with my sniper rifle. If I have a shot. I'll try to take out 1 or 2 before I go on my way.

I do it because I figure, everyone I kill, saves a settler somewhere. Its not like with their hanging bags of body parts that they can claim innocences.

Brotherhood of steel

Agree, but from my perspective it's more to not let free experience points and ammo just walk away.

Also, it's damn hard not to investigate those medium-distance shootings that happens all the time.

Feral Ghouls are my favorite targets. I am usually sneaking about, so if I happen across some Ghoul bodies I usually put a round through their skills just to be certain that they are dead, and stay that way!

If I see a raider lookout I'll go ahead and pop 'em.
Rad scorpions are a must. Just because it is always an epic fight.

When you see a super mutant use the mini nuke launcher of DOOM on them best one so far is still 4 super mutants at once with it had the launcher that launched 2 mini nukes at a time muhuhaha!!!

I can give you the full list of people I will pass up shooting: traders, caravan guards, my own settlers. That's it. Given the unrelenting hostility of the Commonwealth everyone else gets a headshot.

I play a consummate professional in games like this. I'm obviously important to the game and I take my responsibility seriously. I don't like to suffer damage. so I'll arrange for stuff to die as opposed to charging in. I will pull out the big hammer once in a while but that's to end some nasty little small room fight.

I only shoot at my target and ignore most of the wastelands inhabitants, as long as they don't attack me. I'll move around things that I'm not hunting to avoid useless combat.

Works for me. I play on Survival and have not died in days. The opposition has died a lot, almost as much as the halfwit BoS idiots, I'm supposedly aligned with.

Well... Realistically, any enemies I happen upon. But I WILL kill any Children of Atom I come across.

In New Vegas it was Caesar's Legion. In this game ... nah. I'll usually take out baddies but if I'm on my way somewhere and see a baddie that doesn't see me I'll usually mosey on by unless I'm just wanting to shoot something.

Marcy long and preston for me every time i see him coming towards me wearing that pink dress i pistol whip him.

i bring mercy to all in the wasteland. everything dies, no discrimination.

Mole rats. God I hate those things.

Just swat em' or better yet use a nice bayonet. Bugs, dogs and molerats respond well to a good stab.

Don't waste ammo on em'.

Anything that attacks me. I will defend myself to the death.

And Radroaches. Roaches are disgusting!

me too except i dressed him up as Obama.

Anyone who shoots at me first.

After that, synths, mannequins and that frigging monkey.

Not enough world left to put up with fakes.

Apart from allies, only those I can't loot. I consider it unethical to kill someone/something without looting it.