I am not positive how helpful this application is, but I tried it and it may or may not have helped. The one possibly very useful dart from the syringer is the "Endangerol" dart that reduces enemy DR by 25%. The issue is, knowing Bethesda, that 25% could mean just minus 25 armor, minus 25 percent of their total armor (like 100 armor enemy loses 25 armor) or if it applies a negative 25% DR effect that just makes the enemy take 25% more damage. Depending on how it works, it could be handy for boss type enemies. I used it against the mirelurk queen during taking independence before letting her run through a pile of mines in the wall breach. Not sure how much help it was. Anyone else have more solid data on how that effect works? Eventually we will figure it out with the creation kit.