The bug where Piper starts falling down, interrupting story events/combat/conversations is absolutely brutal. It has basically broken my second playthrough. I have reloaded a dozen times, going back over 6 hours, and it has ravaged everything. I can't get through the main story because the conversation between Piper and Nick Valentine is completely broken due to it. I can't go back far enough in my save to get to a point where I can get around it. It's like it has infested every save file I have.
None of the suggested ways of addressing it have worked. It has broken essentially every save file on my hard drive. I beg the team to make a priority of this bug in the next patch, or I will have to abandon all further playthroughs.