1: companions don't use fusion cores for power armor, and they get the carry weight bonus. You can fill them up, take their power armor loot to max weight and fast travel to a settlement for huge hauls.
2: if you find a weapon or piece of armor with a mod that you haven't unlocked, you can replace the component, and then apply the mod to the gun of your choice.
3: cait picks locks, and nick valentine hacks for you. Using them accordingly can save you 3 perks and still give you full access to blocked off areas.
4: you can build stilt houses and concrete walls for your settlements. Concrete floors have alot more leeway with acceptable placement perameters ie: they can phase through alot of walls
5: you can pick up corpses and hold them between yourself and an aggressor, making the corpse take the bullets instead of you.
6: unlike past games, crippling both legs completely immobilizes enemies. Best used on melee opponents and death claws.
7: supply lines from the local leader perk are essential to thriving settlements. You can have one primary farm that feeds every other settlement.
8: vegetable starch, made at any campfire from mutfruit corn tatos and purified water is a renewable sources of adhesive. Paired with the scrounger perk, mods become Much more easily made.
9: drinking from fountains outside combat will save you many a stimpac, especially on survival mode. Don't forget about cooking too.
10: make an effort to balance out your loot. Prewar money is better used for currency than cloth, the same is true of cigarettes. Though weapons are arguably the best renewable sources of steel, they can also fetch you alot of caps
11: drop your auto save time to 5 mins. You'll be glad you did. It's in the settings menu
12: want a particular legendary item? Save before the fight, reload if you didn't get it. To the best of my knowledge the base item won't change but the legendary effect will.
13: even if you don't want to switch your companions, ALWAYS take new ones, then switch back if you want. That way you can send them to a settlement and you don't lose them.
14: you can flash your pipboy light to attract enemy's attention and lead them into a trap.
15: raiders typically aren't morning people. ; )
16: long range-er = less danger
17: power armor let's you breathe under water, but also sinks you straight to the bottom. It's alot easier to get in than out. Cooked mirelurk meat allows you to breath under water as well
18: used power cores sell for the same as unused. This will probably be patched eventually.
19: NPCs will only use stairs if they are clipped to the destination. Ie: if your gonna build on the roof of red rocket, you need a floor clipped to your stairs for npc's to come up
20: scavenger, get it. Get it four times when you can. 'Nuff said
21: download the pipboy app to your cell phone to add a pseudo multiplayer option. One person does the killing, the other picks weapons, monitors vitals, ect. Add to the fun by turning hud transparency all the way up.
22: naming your weapons after the ammo type they use usually keeps them organised at the top of the menu. If they use an ammunition that is spelled, like shotgun shells or microfusion cells, name it starting with AAA and they'll stay with the others.
23: when hacking search for open and close signs in the same line. ($#&) or any other combination. Alternatively, you can scroll through every option and find them. They will either remove a dud answer or refill your attempts.
24: Buffout and the like are the only way to get instant health, which can be extremely useful in survival mode, just be aware, when it wears off, that health is instantly lost.
25: alcohol boosts your strength and therefore your max carry weight. That being said, if you carry so much booze that you need to drink to hold it, your wasting your time unless you're roll playing.
26: when in first person you see the gun held downward, you're in cover. Aiming will make you peek around, and releasing the aim button sends you back into cover.
27: when a companion goes down, you can heal them by clearing the area of hostiles.
28: an enemy drops their current weapon when you cripple their right arm.
29: companions waste powerful ammo and weapons on feeble opponents, but by holding the ammo for certain weapons you can get around this. Just be warned, they will still use it when they see fit, and they may be horribly wrong.
30: not only can you find interesting loot on roofs, they also make excellent vantage points against ground bound baddies.