I was having problems with the game, crashing near diamond city, talking to specific person, going near an area new.
What I did, I deleted the Fallout4, Fallout4Prefs and the fallout4Custom .ini files in the C:\Users\my name\My Documents\My Games\Fallout4\ in order to fix the game.
It works, I have no CTD, except the the mods won't interacts with the game.
I have now in the directory mention above Fallout4 and Fallout4Prefs .ini files.
I got the idea from this web site
http://help.bethesda.net/app/answers/detail/a_id/31648
If you have edited your game's .INI file, we recommend you restore it to its default state. Many issues can be traced to modification of the game's .INI file.
So, I deleted the .ini files hoping the game will fill in the blanks of missing .ini files.
I think I'm missing the .ini file of Fallout4Custom.
How to fix?