I get repeatable CTDs in the opening Vault 111 sequence after Kellog shoots the PC's spouse. This is repeatable. In order to keep playing, I used a save outside the vault to continue. Then I got stuck inside the Museum of Freedom after killing the raiders outside. Now I cannot leave without a CTD at the front door.

I also seem to get periodic CTDs on startup. They appear random and don't seem to be correlated to anything.

I seem to get overall better performance with the beta, and I love how the UI has been fixed to allow for changes to the FOV. However, for now, I'm going to roll back to 1.2. My rig just locked up on the last CTD, and I'd rather not keep that up.

I have been running mods, about 15 or so esps, but I have disabled them for testing purposes, and having them disabled made no difference that I could discern. I will say that when I disable EVERYTHING, and I even disable the ability to mod, the game seems to run without much issue. So...yeah...could be a modded texture or mesh conflict with the update. There are confirmed reports of this, and personally I can replicate a CTD using a particular Texture from a mod called Gore Overhaul on the Nexus.