This whole time I was guessing that specific textures or mods causing my extremely frequent CTD's, but I was wrong. I had Nick Valentine as a companion and at some point I used a mod called Fixed Nick - Gen 2, which allowed Nick to wear any outfit and/or armor. That mod was nice, but later it became impossible to remove as removal cause ALL my SaveGames to crash. SOMEHOW I got rid of the mod, but Nick was still Equipped with outfits he wasn't supposed to, no without a mod that would let that that happen. He wouldn't actually show anything that was equipped. For example, he was Equipped with Combat Armor and in Inventory it was ticked/selected, but what I saw was plain old Nick Valentine in his vanilla suit! I decided to take those Equipped items Nick could not wear and then let Nick go. TO MY EXTRME SURPRISE, IT SOLVED MY CTD CRASHING or at least 90% of it! Once in a while I get an infinite frozen black screen during loading of my SaveGame, but its very rare these days and it doesn't actually kick me to Desktop.

My point is - your mods, textures, meshes, etc. may not be the cause of your problem. It could be a remnant of a previous mod that somehow affected the game when the mod was removed OR it could be something you're carrying, maybe your companion, maybe even your armor or weapon or God knows what. Don't give up - keep trying different scenarios and you'll isolate your problem. I spent about 8 days testing the game for 5-8 hours to get rid of CTD's and after about 50 hours, I got it figured out. No biggie.., right?

Currently there is no proper way to edit the 3D mesh. If you look at nifskope, they have disabled import. Those who did it may not have the full knowledge for this game. Texture replacement is fine but when one starts to edit mesh, you have all sort of problems, reporting of crashes at different locations. So use the mod with care esp. those that modify mesh ...