My char was using both hip fire and scoped aiming in vats. But I've read that the accuracy is the same in both cases and those are just animations, as accuracy is dictated by the accuracy stat of the weapon (and perception obviously). Although a scope can drastically cut off your vats hits, so it's best to just stick to reflex sights.
For vats its best to start out with max agility for max ap points. Then get the bobblehead for 11 agility. Though if you get vats enhanced pistols like the Deliverer this wouldn't be so necessary. Kellog's pistol is nice too. A high perception is also needed for vats, especially with pistols who have poor medium to long range accuracy (compared to rifles), start of with at least 5 perception. Then ingame you can progressively take luck points cause a higher luck means filling your critical meter faster, and luck perks are the best for vats: better criticals to finish off tougher enemies faster, critical banker to always have 3 criticals at your disposal, grim reapers sprint to refill your action points ~every 3 kills, four leaf clover to refill your criticals.
Perks to get: gunslinger whenever possible, action boy to refill your action points faster, concentrated fire that makes you more accurate with each shot (works great with pistols cause you have many shots), penetrator that lets you shoot enemies who are taking cover, through obstacles, gun fu to do more damage to your second enemy and beyond in a vats session, and the luck perks above, especially grim reapers sprint that is practically unlimited action points, thus unlimited vats.