Hi guys.

So I bought a new setup with a Asus Z170 Gaming Pro and installed Windows 10 on it. Now, I've not changed my mouse from my old to my new setup, so I'm still running with my IntelliMouse 3.0 USB.

However, for Fallout 4 I have the mouse re-connecting during gameplay, which results in the Windows cursor appearing in-game, only solved by restarting the game.

I've tried to disable "USB selective suspend setting" in Windows, as well as disabling any possible USB units from powering down in the device manager, however the problem persists.

I didn't experience this issue with my old ABit IP35 Pro and Windows 7, so I guess it's either a buggy motherboard or a buggy Windows 10. I don't experience any other USB related issues, not even with my USB DAC for audio.

Any suggestions?