Spoilers ahead
The quest to find Amelia makes zero sense, as I'd already become leader as this point: there was no option to say to the scientist 'hey, actually I'm with the Institute, I'm gonna kill you and take back your synths'. At the very least, I would have liked an option to reclaim Amelia if she were indeed a synth.
I think this is the only quest I've found so far that isn't fitting in with my personal storyline though.