Is there any way someone could make a mod that saves all your weapon keybinds so you don't have to redo them every time you leave a casino? I like to have all 8 (7 if you count the ammo changer) keys bound at all times, and it's a huge pain having to redo it just because I entered a casino...
I haven't played enough to know why the hotkeys get lost in a casino. My guess is that the casinos take your weapons away and the game doesn't keep track of the hotkeys.
In either case, I think you will need a mod with access to the NVSE function GeyHotkeyItem. With that a mod could track when you enter a casino and record your hotkeys. When it detects you leaving the casino space and you've got your weapons back, it could attempt to reset the hotkeys. That might also need additional NVSE support.
NVSE is probably still a week or so away from a beta release. Then someone would have to write a mod to do this. You can keep track of http://www.gamesas.com/index.php?/topic/1127320-wipz-new-vegas-script-extender-nvse/.