I was thinking of starting a new character, and going the Nuclear Physicist route with PA. Due to role-playing reasons, I kind of wanted to side with Lorenzo Cabot in The Secret of Cabot House (an immortal Director can get a lot done), however I also didn't really want to miss out on Lorenzo's Artifact due to going with Nuclear Physicist.

Having said all this, looking at the stats Lorenzo's Artifact seems like a much worse Gamma Gun from what I can tell - is this true? If so, I'll definitely side with Lorenzo again, as I said the promise of immortality seems like something my player would be keen on for role-playing reasons.

Mod it with an Electric Signal Carrier Antenna, and I think the damage from the telekinesis blast scales with the Demolition Expert perk. All I can tell you is that it works pretty damn well for me, although watch out for the splash damage.

it adds knock back which can be put on a legendary variant so you could make some amazing combos. Freezing, Infuriating, Irradiating, penetrating all make good options.