I found an explosive minigun and an explosive 10mm and I've noticed that after using them for about 30-50 minutes my game will freeze either in the middle of shooting something (and thereby crippling one or more limbs) or when I'm looting clothing off of a corpse that has limbs detached. The screen will freeze and sounds will start looping, and although the task manager says it's not completely frozen, it never recovers.
Some maybe relevant info:
My character is running around with about 30,000 inventory weight. I try to keep it low enough that the game doesn't stutter much when I switch weapons, but it can freeze for about 5-10 seconds when I equip or unequip armor with legendary modifiers, especially ones that affect damage taken.
This wasn't a problem before 1.3.
I'm not using any mods or console commands.
I'm only assuming it's related to crippled limbs because it doesn't happen with any other guns and automatic explosive weapons cripple everything instantly all the time.
Also, I've noticed that when I cripple the legs of a mob, when it respawns, it'll be able to walk around just fine, but its idle animation will still be set to lying on the ground with crippled legs.